About our Super All-In-One ingredients
About Each Ingredient
Our Super All-In-One Supplement Formula's ingredients and dosage amounts have been carefully chosen with your health in mind. We created an all-in-one product from the ground up that’s designed to optimize your health and wellbeing, now and for the long run. Our formulations are 100% based on the most up-to-date, cutting-edge scientific research. We take our business seriously, and your health is our business. You can rest assured that our products contain the micronutrients you need in the amounts that will optimize your health.
Vitamin A (as Retinyl Palmitate)
Many people are more than a little surprised to learn that foods such as carrots and sweet potatoes don’t contain any Vitamin A. These supposed sources of Vitamin A contain what are known as provitamin A carotenoids, which are precursors of the actual Vitamin A that your cells require. Importantly, provitamin A carotenoids, including beta-carotene, are poorly converted into the active form of Vitamin A your body requires, which is retinyl palmitate.
To put this in perspective, even if you drink carrot juice and eat sweet potatoes daily, your cells won’t get enough of the Vitamin A required. Retinyl palmitate, the active form of Vitamin A, is only found in animal products, particularly liver. The fact is that getting enough Vitamin A each day isn’t an easy thing to do unless you consume liver or fish oil supplements that are fortified with actual Vitamin A, i.e., retinyl palmitate. For this reason, supplementing with retinyl palmitate is a crucial step in ensuring that your cells receive enough of this vital micronutrient each day.
Of concern is that many supplements contain provitamin A carotenoids such as beta-carotene, which, again, is poorly converted into the active form of Vitamin A that your cells require. Retinyl palmitate is vital for many bodily functions, including thyroid physiology, protecting against blindness and poor night vision, chronic inflammation and autoimmune diseases, childhood morbidity, complications of childhood measles, diseases of the skin, prevention of diseases per se, and healthy immune function. Retinyl palmitate is also strongly linked to ATP production, making it a key player in maintaining your overall health.
Vitamin B1
Vitamin B1 (thiamine) is an essential micronutrient that humans cannot produce but require for many life-sustaining functions. Thiamine was more prevalent in the food supply before the Industrial Revolution, but various factors have historically limited the absorption and utilization of this crucial vitamin in humans. Thus, thiamine deficiency is common, and health issues are likely to develop when thiamine supplies aren’t constantly replenished. Thiamine was the first B vitamin identified, so it’s named B1.
One of the challenges with thiamine is its poor absorption in the gastrointestinal tract, even when supplemented with large doses. However, benfotiamine, a synthetic form of thiamine, offers a unique solution. It significantly enhances the absorption of thiamine by your cells, leading to potent health benefits. This distinct advantage of benfotiamine over traditional thiamine supplementation is an excellent example of how scientific breakthroughs can guide healthcare decisions and improve health.
Scientific studies have consistently demonstrated the remarkable health benefits of benfotiamine supplementation. For instance, it has been found to increase serum thiamine levels by 5-6 times, leading to a significant boost in cellular thiamine uptake. This, in turn, is associated with a range of powerful health benefits. Notably, benfotiamine supplementation has shown promise in improving conditions like neurodegenerative diseases and diabetes, which are strongly linked to thiamine deficiency.
Given the prevalence of thiamine deficiency and its serious health consequences, benfotiamine is a critical component of our Super All-In-One Supplement Formula. After examining the results of numerous benfotiamine studies, we elected to include 500 milligrams of this impressive micronutrient in our Super All-In-One Formula. We do our best to keep things light, but we’re all business when it comes to formulating products that can make a difference in your long-term health.
Vitamin B2
Vitamin B2 (riboflavin) is the 2nd B vitamin to be discovered and was appropriately named Vitamin B2. This brightly colored vitamin supports many functions, including energy (ATP) production and keeping oxidative stress in check. Although riboflavin is essential to creating energy in the mitochondria, more research needs to be performed to determine how much is required to optimize mitochondrial function and long-term health.
Riboflavin’s RDA (Recommended Daily Allowance) is between 1.1 mg and 1.6 mg daily, but the body can absorb 20 times this amount from food and supplements. Like all B vitamins, riboflavin is water soluble and is quickly flushed from the blood. After thoroughly reviewing the scientific literature on riboflavin and testing different dosages, we included 62.50 mg of riboflavin 5’-phosphate in our Super All-In-One Formula.
Vitamin B3
All B vitamins, including niacin, are water-soluble compounds that support ATP (energy) production and healthy metabolism. Two primary types of niacin are used in dietary supplements: niacinamide and niacin. Niacinamide and niacin have slightly different effects on the body. Niacinamide helps treat skin issues, whereas niacin, also called nicotinic acid, impacts cholesterol and triglyceride levels. Niacin is a vasodilator, and taking this form of vitamin B3 in large doses produces what’s known as a niacin flush.
Unlike vitamins B1 and B2, which can be taken in large doses, it’s not recommended to supplement with large doses of niacin, particularly nicotinic acid—even though doing so is common. It’s well-documented that nicotinic acid reduces cholesterol and triglyceride levels, especially in high doses. However, large doses of nicotinic acid interfere with the release of triglycerides from fat cells, which limits the capacity to tap into and burn fat stores.
Thus, relying on megadoses of nicotinic acid to lower cholesterol and triglyceride levels can inadvertently interfere with burning fats, inevitably leading to unwanted health consequences. Rather than using large doses of niacin to reduce cholesterol and triglyceride levels, it’s necessary to take action to heal your metabolism and improve your overall health.
Vitamin B4 (Choline Bitartrate)
Choline bitartrate (we’ll call it choline for short), sometimes referred to as vitamin B4, is one of the least-known and least-talked-about essential micronutrients. Choline deficiency—which is very common—is associated with a variety of health issues, including hypomethylation, elevated homocysteine levels, decreased methionine levels, reduced liver stores of folate, significantly reduced s-adenosylmethionine (SAM) and significantly increased s-adenosylhomocysteine (SAH), NAFLD (fatty liver disease), and muscle damage.
Of concern is that less than 10% of Americans get enough choline daily to prevent liver damage. Humans can make small amounts of choline, reducing SAM and increasing SAH and homocysteine. Choline is necessary for proper liver and brain function and for creating fats and cell membranes.
A growing body of research confirms that single nucleotide polymorphisms (SNPs) impair the absorption and utilization of choline in humans. This makes it necessary for many humans to consume choline above the recommended daily intake to meet their needs for this essential micronutrient. In addition, pregnant and breastfeeding women must consume ample amounts of choline, because neurological, psychological and cognitive development rely on it.
When choline and betaine anhydrous (trimethylglycine) are consumed in adequate amounts, they can offset deficiencies in folate (vitamin B9), thus rescuing a vital component of the methylation cycle. Given the scarcity of choline in the diet and the numerous health issues choline deficiency is associated with, we shoehorned a whopping 1000 mg (1 gram!) of it into our Super All-In-One Supplement Formula.
Vitamin B5
Vitamin B5, more formally known as pantothenic acid, is a vitally important B vitamin that plays a crucial role in mitochondrial energy (ATP) production. The word pantothenic is derived from the Greek pantothen, which means everywhere. Pantothenic acid’s name draws from its widespread distribution in many foods. This led to the erroneous belief that a well-balanced diet provides ample vitamin B5. However, liver is the only food rich in this critically essential micronutrient.
Pantothenic acid is a direct precursor of an important compound known as coenzyme A. Coenzyme A is needed for many processes in the body and is the direct precursor of acetyl CoA. This compound enters the Krebs Cycle, wherein it’s converted into ATP. Thus, pantothenic acid directly supports the creation of cellular energy, and marginal deficiencies in this micronutrient may result in impaired ATP production.
Pantothenic acid deficiency is strongly linked to neurodegeneration, dementia and cardiovascular disease. More scientific investigation is needed into the daily requirements of pantothenic acid in humans. Current dietary recommendations are based on decades-old investigations that aim to determine the amount of vitamin B5 required to prevent disease. Similarly, no known studies have investigated the amount of pantothenic acid needed to support long-term optimal health.
Vitamin B6
Vitamin B6 (pyridoxine) is an enzymatic cofactor that catalyzes 140+ biochemical reactions in the body. Enzymes allow chemicals to interact at lightning speed, producing vast numbers of essential compounds. More than half of Americans are deficient in vitamin B6. Deficiencies are associated with cardiovascular disease and a variety of physical and psychological symptoms. Many supplements contain pyridoxine, a form of vitamin B6 with limited bioavailability. Our products rely exclusively on pyridoxal 5 phosphate, which is the active form of this essential B vitamin.
Vitamin B7
Like vitamin B6, vitamin B7 (biotin) is an enzymatic cofactor needed for numerous biochemical reactions in the body. Biotin is necessary for healthy neurological function, blood glucose levels, and hair and fingernails. Biotin is required only in small amounts each day, but it’s hard to get enough of it from our foods. Liver is rich in biotin, and eggs, salmon, pork and beef also contain this essential micronutrient. We include biotin in our Super All-In-One Supplement Formula to ensure your cells have sufficient amounts of this vital micronutrient.
Vitamin B8 (Myo-Inositol)
Myo-inositol, sometimes referred to as Vitamin B8, is a “jack-of-all-trades” compound that has many uses in the body. It helps regulate blood sugar, positively affects the balance of neurotransmitters and mood, balances hormones, is helpful in managing polycystic ovarian syndrome (PCOS), and improves fecundity. Myo-inositol also exhibits antioxidant and anti-inflammatory properties.
Vitamin B9
Vitamin B9 (folate) is an essential B vitamin that humans have difficulty getting enough of from their diet. It’s estimated that 33% of Americans don’t get enough dietary folate, but what really impairs the amount of folate your cells absorb each day are common single nucleotide polymorphisms (SNPs). Many are familiar with the infamous MTHFR (methylenetetrahydrofolate reductase) SNP. This SNP is associated with a variety of health issues, particularly increased homocysteine levels and psychological disturbances.
To ensure that your cells absorb ample amounts of folate, our Super All-In-One Supplement Formula contains 400 micrograms of 5-methyltetrahydrofolate (5-MTHF), the activated and bioavailable form of folate.
Vitamin B12
Vitamin B12 (cobalamin) is absolutely positively one of the most important and lacking nutrients in the human diet. A robust body of research links vitamin B12 deficiencies with neurodegenerative diseases, megaloblastic anemia, bone marrow issues, hyperhomocysteinemia, oxidative stress, pain syndromes, and various psychological issues.
A primary reason for widespread vitamin B12 deficiencies is that many humans poorly absorb vitamin B12 from the gastrointestinal tract. Malabsorption of vitamin B12 increases with age and is observed in cross-cultural studies around the globe. Furthermore, single nucleotide polymorphisms (SNPs) further interfere with cellular B12 absorption.
Fortunately, vitamin B12 is readily absorbed when placed beneath the tongue, a process known as sublingual supplementation. Given the difficulties humans have absorbing vitamin B12, sublingual B12 supplementation is an absolute necessity for nearly all humans.
Vitamin B12 is so essential to all aspects of your health that we created a super-potency sublingual B12 powder unlike any other B12 product available today. Our Super Sublingual B12 contains 10,000 micrograms of pure methylcobalamin, the most bioavailable form of B12. It also contains pure quercetin, acerola and organic lemon juice powders; these powders are rich in bioflavonoids, which convey impressive health benefits.
When you order our Super All-In-One Supplement Formula, we also ship you a separate Super Sublingual B12 Powder package. There’s a scoop in the package, and getting the B12 your cells desperately need each day is as simple as placing a scoop of powder beneath your tongue and allowing it to dissolve. That’s all there is to it!
We make our Super Sublingual B12 Powder in small batches each week to ensure the highest freshness and potency of this critical micronutrient. We also double-seal our Super Sublingual B12 Powder in two bags to protect it from the elements.
Vitamin C
Vitamin C is a water-soluble essential micronutrient that must be regularly included in the diet. This is because, unlike most mammals, humans cannot create vitamin C in their bodies. Furthermore, the absorption and utilization of vitamin C in humans are strongly affected by single nucleotide polymorphisms (SNPs). SNPs are slight genetic alterations that affect how genes function in your body. SNPs impair the absorption and utilization of many micronutrients, including vitamins B1, B9 and B12.
Vitamin C-specific SNPs are widespread in humans and strictly limit the amount of vitamin C your cells absorb daily. Fascinatingly, humans have such a limited capacity to absorb vitamin C that doses larger than 250 mg per day don’t appreciably increase intracellular vitamin C levels. Thus, megadoses of vitamin C are of little benefit and aren’t recommended.
Vitamin C, also known as ascorbic acid and ascorbate, is available in various forms. Most of the vitamin C in dietary supplements is synthetically created in laboratories, while some are sourced from natural sources such as acerola. It's important to note that the amount of vitamin C your cells absorb each day is significantly influenced by SNPs, and both synthetic and natural forms of vitamin C are equally effective. This information can help you make informed choices about your vitamin C intake.
Vitamin D3
Unless you consume wild-caught salmon or cod liver oil daily, it’s guaranteed that you’re not getting enough vitamin D from your diet to meet your needs for this essential micronutrient. Unless that is, significant amounts of your skin are exposed to midday summertime sun, allowing your body to produce the vitamin D3 required. Unfortunately, few humans get enough of the vitamin D3 they need from either source, making supplementation necessary.
Vitamin D deficiency is associated with cancer, heart disease, high blood pressure, impaired balance, falls, osteoporosis, fractures, autoimmune diseases, Parkinson’s disease, cognitive decline and many other health issues and diseases. To ensure that your cells absorb enough of this vital vitamin, our Super All-In-One Supplement Formula contains 50 micrograms (2000IU) of cholecalciferol, a highly bioavailable form of vitamin D.
Vitamin E (Acetate and Succinate)
Vitamin E is a critically important fat-soluble micronutrient that protects your cell membranes and circulating blood lipids (LDL particles and polyunsaturated fatty acids) against the damaging effects of oxidation. By protecting LDL particles, PUFAs and cell membranes, vitamin E reduces atherosclerosis, a major factor in the development of cardiovascular disease.
It’s estimated that ~93% of Americans are deficient in vitamin E, and these estimates are likely low. First, very few foods in the Western diet are rich in natural sources of vitamin E. Secondly, many multivitamin supplements contain dl-alpha-tocopherol, the synthetic form of vitamin E, which is poorly absorbed and less bioavailable than natural forms of vitamin E. Synthetic vitamin E is associated with health issues, which inadvertently led many to avoid supplementing with natural vitamin E. Avoiding natural vitamin E compounded existing vitamin E deficiencies, virtually guaranteeing vitamin E deficiency around the globe. To clarify, synthetic forms of vitamin E must be avoided, but natural vitamin E is among the essential micronutrients to supplement daily.
Given vitamin E’s crucial antioxidant function, the Recommended Daily Intake (RDI) established for humans is indisputably low. Bizarrely, RDIs are set just high enough to prevent disease and infirmity but not high enough to provide lasting health benefits, and vitamin E is no exception.
The RDIs for vitamin E were established in the 1950s; these guidelines were created based on the absolute minimum amount of vitamin E needed to keep red blood cells from being damaged by free radicals in a test tube. For reasons that aren't clear, these guidelines haven’t been updated since. This is important, because the RDI for vitamin E (and other essential micronutrients) wasn't set after rigorous testing to determine the optimal amount humans require to experience full-glowing health. Everything has changed dramatically since the 1950s—except the RDIs for the essential nutrients humans require to remain alive.
Providing your cells with ample amounts of natural vitamin E reduces all-cause mortality, i.e., death from any and all causes. Our Super All-In-One Supplement Formula is rich in this essential fat-soluble micronutrient, which protects your cells against free-radical damage and safeguards your long-term health.
Vitamin K1
Humans require two types of vitamin K each day: vitamin K1 and vitamin K2. Vitamin K1, known as phylloquinone, is contained in leafy greens, broccoli, and other vegetables. There are several forms of vitamin K2, which are referred to as menaquinones. Vitamin K1 derives its name from the German koagulation, i.e., coagulation. This is because the liver uses vitamin K1 as a clotting factor; the human body relies on several clotting factors to turn blood from a liquid into a gel, thus preventing hemorrhaging.
Unlike other fat-soluble vitamins, vitamin K doesn’t appreciably accumulate in the body and must be consumed regularly. To ensure that your cells receive ample amounts of this critical fat-soluble nutrient, we include this essential micronutrient in our Super All-In-One Supplement Formula.
Vitamin K2 (MK7)
The liver relies on vitamin K1 to produce clotting factors, but the brain, kidneys, breasts and vasculature preferentially use vitamin K2 to create clotting factors. Vitamin K2 also plays a crucially important role in bone health. Vitamins K1 and the various types of K2 (menaquinones) are structurally similar molecules, and some of their functions overlap. However, due to their unique functions, researchers have suggested classifying them as separate micronutrients, each with their own Recommended Daily Intake (RDI).
Two types of vitamin K2 are commonly used in dietary supplements: MK-4 and MK-7. Importantly, studies demonstrate that MK-4 doesn’t appreciably increase serum vitamin K levels, whereas MK-7 does. The human diet largely lacks MK-4 and MK-7 forms of vitamin K2. MK-4 is contained in cheeses and fermented foods, and MK-7 is only found in natto, a traditional fermented soy product. Our products include ample amounts of MK-7, which protects blood vessels, ensures healthy clotting, and supports healthy bones.
Phosphorus (as Dicalcium Phosphate)
Phosphorus has many functions throughout the body. It’s an integral component of teeth and bones, DNA and RNA, and the phospholipid bilayer surrounding each cell. Phosphorus is also a key component of ATP, i.e., adenosine triphosphate, the energy that’s endlessly created around the clock in all cells. Considering the number of critical functions that phosphorus supports, we include ample amounts in our Super All-In-One formula.
Iodine (as Potassium Iodide)
Sufficient iodine levels are required to prevent many developmental disorders and diseases, including cancer and all thyroid issues. Approximately 2 billion humans worldwide are iodine deficient, and 1 billion are hypothyroid. Thyroid issues and iodine deficiency devastate all aspects of mammalian health. Iodine deficiency disorders (IDD) are the leading cause of preventable mental impairment worldwide, including brain damage, irreversible mental retardation and cretinism, the most severe form of mental retardation.
Iodine has been used to treat a surprisingly broad array of health issues for thousands of years. However, as medications and surgical procedures became increasingly popular, they supplanted the use of “folk” medicines such as iodine, and its use fell by the wayside. Large doses of iodine were used to treat thyroid disorders, poisoning and more. But by 1980, iodine was scarcely included in the Western diet, and the Recommended Daily Allowance (RDA) for iodine was lowered to a paltry 150 micrograms per day, which is the bare-bones amount required to prevent goiter formation in most humans.
However, respected peer-reviewed journals recommend supplementing with at least 3 mg of iodine daily, which is 20 times the current RDA. Furthermore, the typical mainland Japanese diet provides far more than 3 mg of iodine daily—it’s estimated that the Japanese consume between 7 and 13.8 mg of iodine per day. Fascinatingly, the Japanese enjoy the longest life expectancy of all nations, outliving Americans by a whopping five years.
Given the overwhelming evidence that iodine deficiency is associated with the onset and progression of various diseases, we include 3 mg of iodine in our Super All-In-One Supplement Formula. It bears repeating that we’re a science-driven company. We rely on cutting-edge science to help the world become healthier and minimize the risk of diseases.
Magnesium Glycinate and Citrate
So many magnesium supplements are on the market that choosing the best formulations can be confusing. Many supplement companies sell several types of magnesium, making it hard to know which ones work best. To solve the magnesium dilemma, we spent several years reviewing the evidence and testing different formulas to determine which ones deliver magnesium to the cells. When it was all said and done, we included a combination of magnesium glycinate and magnesium citrate in our Super All-In-One Formula.
Magnesium supplements can be broadly classified as inorganic and organic. Inorganic magnesium supplements contain quite a bit more magnesium than organic formulations. And while that’s the case, inorganic magnesium has very low bioavailability, and only a small amount makes it into your cells. On the other hand, organic magnesium contains less magnesium but delivers considerably more of it to your cells. Thus, organic magnesium formulations are the best choice for dietary supplements.
Studies show that magnesium glycinate and magnesium citrate (organic forms of magnesium) deliver the most magnesium to the cells. Magnesium glycinate combines magnesium with two molecules of glycine. Because this formula contains two glycine molecules, it’s commonly called magnesium bisglycinate. Glycine is an amino acid with a wide variety of impressive health benefits. Glycine has a calming effect on the nervous system, but it also improves immune function, decreases inflammation and improves gastrointestinal disorders. Magnesium citrate combines magnesium and citric acid. Citric acid, a common compound of citrus fruits, isn’t the same as vitamin C (ascorbic acid). However, it, too, is associated with health benefits.
Magnesium is the fourth most abundant mineral in the body. Your cells require magnesium to create more than 300 enzymes to synthesize proteins and nucleic acids, regulate blood sugar, contract muscles, support nerve function, regulate blood pressure, and support ATP production. Magnesium deficiency increases all-cause mortality, which is why it’s so concerning that 68% of Americans are deficient in this crucial micronutrient.
With this in mind, our Super All-In-One Supplement Formula contains more than 2000 mg (2 grams) of magnesium glycinate and citrate—enough to fill three capsules! That’s a lot of magnesium, but it takes a lot to safeguard your health. We don’t cut corners; we help people turn them.
Zinc Bisglycinate
Like magnesium glycinate, zinc bisglycinate is a periodic table element bound to two glycine molecules. Magnesium and zinc are metals, and binding them with glycine increases their absorption from the gastrointestinal tract. Scientific studies show that zinc bisglycinate is the most bioavailable zinc formulation, which is why it’s the only formula we use. Zinc bisglycinate is also called zinc glycinate and zinc picolinate.
Zinc supports thousands of cellular functions. It’s a key component of enzymes and is needed for protein synthesis and cell division. Unless you regularly consume oysters or liver, it’s recommended to supplement with zinc daily. As is the case with all micronutrients, it’s important to get the right amount each day—not too much and not too little. Your daily zinc requirements vary based on many factors, including the amount of copper you consume.
Estimates vary, but it’s generally agreed that a healthy zinc/copper ratio is between 8:1 and 15:1. This means that for every 8-15 mg of zinc consumed, 1 mg of copper is necessary. An imbalanced zinc/copper ratio is one of humans' most common mineral imbalances. Both minerals are essential for life, but the ratio is more important than the amount of either mineral.
Elevated copper levels, especially in the presence of diminished zinc levels, contribute to a wide range of diseases and health issues. These include Alzheimer’s Disease, diabetes, age-related macular degeneration, impaired immune system function, atherosclerosis, sickle cell diseases, gastrointestinal diseases such as Crohn’s disease, diarrhea, hypertension, autism, fatigue, muscle and joint pain, headaches, childhood hyperactivity, depression, insomnia, senility, premenstrual syndrome, childhood neurological disorders, schizophrenia, panic attacks, headaches, chronic fatigue immunodeficiency syndrome (CFIDS), night blindness, and assaultive behaviors. In addition, low zinc and high copper are associated with all-cause mortality.
Measuring the amount of zinc and copper in the blood yields inconclusive results, making it challenging to test for this critical ratio. Even in cases of zinc deficiency, the amount of zinc measured in the blood may be within healthy limits. Thus, it’s best to consume foods that keep your zinc/copper ratio within healthy limits while limiting the intake of foods that cause it to become imbalanced. Following a vegetarian diet, especially one rich in grains, nuts and seeds, can inhibit zinc absorption, unbalancing the zinc/copper ratio and further increasing the need for zinc supplementation.
The dosage of each micronutrient included in our Super All-In-One Supplement Formula has been painstakingly determined; the above details about zinc and copper are just one example of why this is so. After carefully considering as many factors as possible, we arrived at a zinc dosage for our Super All-In-One Supplement Formula that’s safe and effective for everyone. If you have specific needs for zinc, please let us know, and we’ll do our best to create a custom formula specifically for you.
Selenium (as L-Selenomethionine)
Selenium is a periodic table element crucial to health and wellness. It is needed to regenerate vitamin E and is a component of the glutathione peroxidase family (GPX), a family of eight selenium-containing antioxidant enzymes that neutralize free radicals. Thus, selenium plays a major role in protecting cells from the damaging effects of oxidative stress.
As if that’s not enough, selenium is crucial to thyroid physiology. Iodine is the star of thyroid physiology, and selenium is its trusty sidekick. Iodine deficiency has tragic consequences, and the same applies to selenium. Like iodine, selenium is a periodic-table element commonly deficient in the soil. Iodine is the main component of thyroid hormones, and selenium is the main component of deiodinases.
The thyroid gland produces thyroid hormones, especially T4 and T3. All cells absorb thyroid hormones, which guide and direct cellular metabolism. Roughly 75% of the thyroid hormones produced by the thyroid gland are T4. T4 consists of one atom of the amino acid tyrosine and four atoms of iodine. T4 is an inactive hormone that must be converted into T3 to have effects within the cells.
The conversion of T4 into T3 occurs inside every cell in the body. Removing one atom of iodine from T4 to yield T3 is known as deiodination, a selenium-dependent biochemical reaction. Without selenium, thyroid hormones cannot be activated within the cells, resulting in cellular hypothyroidism. Thus, iodine deficiency impairs the thyroid gland’s production of thyroid hormones; selenium deficiency impairs deiodinase activity, resulting in the underconversion of T4 to T3 and, therefore, hypothyroidism. The consumption of alcohol, coffee, conventionally produced eggs and white rice contribute to selenium deficiency, as does smoking.
Selenium Prevents Free Radical Damage Within the Thyroid Gland
Selenium is highly concentrated in the thyroid gland. When selenium is deficient, the thyroid gland cannot produce sufficient quantities of antioxidants, resulting in free radical damage to the thyroid gland. The thyroid gland produces large amounts of reactive oxygen species (ROS) in creating thyroid hormones; therefore, it must have adequate stores of antioxidants to neutralize them and avoid free radical-induced damage. These antioxidants, e.g., glutathione peroxidase and thioredoxin (Thigh-oh-re-DOX-in) reductase, depend on selenium and cannot be produced without it.
Selenium Deficiency Damages the Thyroid Gland
Severe selenium deficiency results in irreparable damage to the thyroid gland. Free radical damage to the thyroid gland caused by inadequate antioxidant production is associated with Hashimoto’s thyroiditis, an autoimmune thyroid disease. Selenium deficiency, which is surprisingly common, is a prevalent cause of thyroid disease. Along with selenium, high concentrations of iodine within the thyroid gland also protect it against the damaging effects of elevated levels of hydrogen peroxide.
Selenium and Autoimmune Thyroiditis
Placebo-controlled studies demonstrate that supplementing with 200 micrograms of selenium daily (especially selenomethionine, a more bioavailable form of selenium) significantly reduces the indicators of autoimmune thyroiditis. However, levothyroxine (T4) does not appreciably reduce these indicators. Several studies confirm that continued supplementation with selenium gradually reduces autoimmune thyroiditis antibody levels.
Selenium Protects the Thyroid Gland Against Excess Iodine Uptake
Furthermore, adequate selenium supplementation protects the thyroid gland against excess iodine intake, a crucial point when supplementing with iodine. The current recommended dietary intake of selenium is 55-75 micrograms daily. However, the benefits of selenium supplementation emerge at doses of 200 micrograms per day, prompting some scientists to suggest increasing the recommended daily intake of selenium to 200 micrograms daily. The Japanese diet, which is high in iodine, is also high in selenium.
It’s abundantly clear that Super Empowered Supplements isn’t just another supplement company. Rather than copycatting other supplements, we started with a blank slate. We developed a revolutionary product based on top-quality scientific studies investigating the link between micronutrients, health and disease. We take our business seriously, and your health is our business.
A crucial consideration when determining micronutrient dosage is serum half-life, which is the amount of time before half of it is removed from the blood. Another essential consideration is micronutrient bioavailability. Selenium has a long serum half-life, which increases with continued use. Our Super All-In-One Supplement Formula contains L-Selenomethionine, a highly bioavailable form of selenium. Given these factors, we settled on a daily dose of 125 micrograms of L-selenomethionine. Thus, when combined with dietary intakes of selenium, your combined intake of this crucial micronutrient will be safe, effective, and well below the level at which selenium can pose health risks.
Potassium Citrate
The human diet is rich in potassium, but even still, most people benefit from supplementing with a small amount each day. Potassium takes a backseat to calcium, magnesium and sodium chloride (salt) in terms of familiarity. Still, you require more potassium each day than calcium, magnesium and sodium chloride combined.
Potassium, Blood Pressure, Bone Density and More
Consuming enough potassium lowers blood pressure, increases bone mineral density, decreases the risk of cardiovascular disease, stroke and renal disease, and helps regulate blood sugar. For all of its impressive attributes, however, potassium’s most-discussed feature is its ability to reduce blood pressure. The American Heart Association estimates that increasing potassium intake to 3,500 milligrams per day would decrease hypertension in the US by 17%, thus increasing the life expectancy of Americans by 5.1 years. (5.1 years is an eternity in terms of life expectancy.)
The Ratio of Potassium and Sodium Is What Matters Most
It’s estimated that our ancestors consumed 3-10 times more potassium than sodium each day. The modern Western diet has reversed this trend: the modern Western diet contains roughly three times more sodium than potassium. Potassium and sodium both play a role in hypertension and its associated risks. Still, the ratio of potassium and sodium consumed daily significantly affects blood pressure more than potassium intake or sodium intake per se. It’s all about the ratio of these two essential micronutrients. An increased sodium:potassium ratio is strongly associated with all-cause mortality.
The RDA for potassium has been raised to a stratospheric 4,700 milligrams per day to offset the stratospheric sodium content of the modern Western diet. Americans consume an average of 3,400 milligrams of sodium daily, roughly equivalent to 1.5 teaspoons of salt. If you consume a lot of salt, it’s recommended to also consume a lot of potassium to offset the hypertensive effects of a high-sodium diet. The lower your daily salt consumption, the less potassium you must consume to benefit from a healthy sodium:potassium ratio.
Potassium and Osteoporosis
Osteoporosis is associated with low levels of vitamins D3 and K2, and a growing body of research points to potassium deficiency as another contributing factor of osteoporosis. Numerous studies show a clear connection between supplementing with potassium citrate and increased bone mineral density.
Given potassium’s impressive health benefits, our Super All-In-One Supplement Formula contains nearly an entire capsule of it each day. However, if you consume processed and restaurant foods or add a lot of salt to home-cooked meals, you may require additional potassium.
Trimethylglycine (Betaine Anhydrous)
Trimethylglycine, also known as betaine anhydrous, plays a key role in methylation. In simple terms, methylation is the addition of a small molecule known as a methyl group to various compounds and structures within your body. A methyl group is one carbon atom attached to three hydrogen atoms, designated as CH3 (the ‘C’ is shorthand for carbon, and ‘H3’ stands for three hydrogen atoms). Methyl groups are fundamental building blocks of carbon-based molecules, structures and gasses. As its name implies, trimethylglycine contains three methyl groups, and is thus a potent methyl donor.
An incalculable number of methyl groups are needed to produce many of the compounds your body requires to sustain itself. Methyl groups create dopamine, serotonin, adrenaline, phosphatidylcholine (lecithin), phospholipids, myelin, creatine, carnitine, glutathione and taurine. In addition, methyl groups methylate DNA and RNA. Last but not least, methyl groups methylate (convert) homocysteine into methionine, which is crucial to every aspect of life and health.
Methylation also plays critical roles in energy production, hormone regulation, fecundity, mood, memory and mental health, histamine and allergies, protection against autoimmune diseases, detoxification, neurotransmitter production, and methylation is necessary to maintain the integrity of cell membranes and the myelin sheath overlying nerves. Suboptimal methylation, which is very common, is associated with many symptoms. These include mental and muscle fatigue, brain fog, cancer, aging, malaise, and mood disorders such as anxiety and depression. Impaired methylation is significantly associated with all-cause mortality.
Consuming enough betaine anhydrous improves the outcomes of several human diseases, including obesity, diabetes, cancer, and Alzheimer’s disease. However, betaine anhydrous is lacking in the human diet, making supplementation necessary. Our Super All-In-One Supplement Formula contains 1000 mg (1 gram) of betaine anhydrous per day, which aligns with the amount required for the powerful health benefits of this critical micronutrient.
Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA)
One of the most pressing healthcare issues humans face is chronic inflammation. Chronic inflammation has many causes, but chief among them is an overabundance of dietary proinflammatory omega-6 oils and a relative lack of the anti-inflammatory omega-3 oils docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA).
It’s widely accepted that a balance existed between proinflammatory omega-6 oils and anti-inflammatory omega-3 oils in the human diet until roughly 1850. This crucial balance has continually shifted in favor of omega-6 oils since that time, resulting in devastating health consequences. This is because proinflammatory omega-6 oils initiate and sustain the immune response, and the omega-3 oils DHA and EPA resolve it. Thus, an excess of proinflammatory oils and a lack of anti-inflammatory omega-3 oils—which characterize the Western diet—is, per se, chronic inflammation.
This matters, because chronic inflammation underlies all diseases and health issues. To illustrate this point, consider this paragraph, which is the introduction of a 2012 research article (published in EMBO Reports), a peer-reviewed scientific journal:
An increasing body of evidence shows that chronic inflammation causes and advances many common diseases…. Inflammation has long been a well-known symptom of many infectious diseases, but molecular and epidemiological research increasingly suggests that it is also intimately linked with a broad range of non-infectious diseases, perhaps even all of them.
In other words, chronic inflammation is potentially associated with all diseases. Putting the brakes on chronic inflammation is synonymous with balancing your omega 3:6 ratio, which requires minimizing proinflammatory foods and consuming an abundance of anti-inflammatory foods. Balancing this ratio is a two-year process when making healthy dietary choices, and is exponentially longer in the face of unhealthy dietary choices.
Dietary anti-inflammatory omega-3 oils DHA and EPA are limited to seafood, particularly fatty fish such as salmon. However, some types of algae are rich in DHA and EPA, and are an excellent source of these vital omega-3 oils. We include 1000 mg (1 gram) of high-quality algae powder in our Super All-In-One Supplement Formula, which provides you with a daily dose of these all-important omega-3 oils.
Quercetin
Quercetin is a bioactive flavonoid found in various plants. It has antioxidant, anti-allergenic, antibacterial, antiviral and vasodilating properties. Quercetin is one of the most widely used bioflavonoids in treating metabolic and inflammatory conditions. It exerts anti-allergy effects by inhibiting the release of histamine. It demonstrates potent antibacterial effects against nearly all bacteria, including gastrointestinal, urinary, respiratory and dermal colonizers. We include ample amounts of this impressive compound in our Super All-In-One Supplement Formula and our Super Sublingual B12 powder.
Acerola
Acerola is an evergreen shrub or small tree that produces red berries rich in vitamin C and a wide range of phytonutrients. These include carotenoids, phenolics, anthocyanins and flavonoids. These compounds possess diverse bioactive properties and exhibit potent antioxidant and anti-inflammatory properties. Impressively, acerola berries contain 50-100 times more vitamin C than citrus fruits, making it one of the richest natural sources of vitamin C. Given acerola’s impressive characteristics, we include it in our Super All-In-One Supplement Formula and our Super Sublingual B12 powder.